Postdoctoral Research Associate in Functional Amyloid Biology

University of Sydney
Full time Full day
Darlington


  • Full time fixed term until December 2022




  • Opportunity within the School of Medical Sciences to support the research of the Functional Amyloid Biology Group



  • Base Salary $95,047- $105,305+ 17% superannuation


About the opportunity


We are seeking to appoint a Postdoctoral Research Associate to implement, conduct, manage and supervise ongoing research projects within the Functional Amyloid Biology Group.


Led by Professor Margaret Sunde, the Functional Amyloid Biology Group (FABLab) investigates the formation, structure and biological impact of protein amyloid fibrils that have important roles in mammals and microorganisms. Although amyloid fibrils were first identified in association with human disease including Alzheimer's and Type 2 diabetes, protein assemblies that have similar structural features but which convey functional properties, are now widely recognised as key to processes such as programmed cell death, hormone regulation, melanin synthesis, biofilm formation and innate immunity. Current projects in the group focus on understanding the structural basis of functional amyloid assembly within the programmed cell death pathway necroptosis; targeting the functional amyloid assemblies that contribute to fungal infectivity and pathogenesis with a view to novel antifungal agents; and super-resolution imaging of pathological and functional amyloid structures.


In this role you will:




  • optimise the production of multiple recombinant proteins, from cloning through to purification




  • perform a diverse range of biochemical and biophysical experiments to characterise the structure and self-assembly properties of diverse amyloidogenic proteins




  • perform other support tasks associated with general laboratory experimentation, including data entry, literature searches and grant applications




  • write scientific communications intended for publication in refereed journals



  • assist to supervise graduate and honours level undergraduate students during the course of specific projects.


About you


The University values courage and creativity; openness and engagement; inclusion and diversity; and respect and integrity. As such, we see the importance of recruiting talent aligned to these values and are looking for a Postdoctoral Research Associate who has:




  • a PhD in an appropriate discipline (Biochemistry, Medicinal Chemistry, Pharmacology) (those who are near completion will also be considered)




  • ability to set up and monitor new and existing experimental projects and demonstrated laboratory skills in molecular biology techniques, protein purification and biophysical analysis, including single molecule approaches




  • experience in amyloid assays (desirable)




  • experience and demonstrated expertise in transmission electron microscopy, NMR or crystallography (desirable)



  • proven ability to prepare and to write scientific communications and to prepare and deliver verbal communication of data at laboratory and other scientific meetings.


This is an excellent opportunity to further develop your research profile in a well-funded, collaborative team environment.


Closing date for applications


11.59pm, 14 November 2021


Sponsorship / work rights for Australia


Visa sponsorship is only available for this position for candidates who are currently located within Australia.


Australian Temporary Residents currently employed at the University of Sydney may be considered for a fixed term contract for the length of their visa, depending on the requirements of the hiring area and the position.


Pre-employment checks


Your employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.


EEO statement


The University of Sydney is committed to diversity and social inclusion. Applications from people of culturally and linguistically diverse backgrounds; equity target groups including women, people with disabilities, people who identify as LGBTIQ; and people of Aboriginal and Torres Strait Islander descent, are encouraged.


How to apply


Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.


For employees of the University or contingent workers, please login into your Workday account and navigate to the Career icon on your Dashboard. Click on USYD Find Jobs and apply.


For a confidential discussion about the role, or if you require reasonable adjustment or support filling out this application, please contact Linden Joseph or Rebecca Astar, Recruitment Operations, at [email protected]


© The University of Sydney


The University reserves the right not to proceed with any appointment.


Closing Date: 14 November 2021

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